Of concern to any user of Winstrol during a cycle should be its intoxicating effect on the liver . The drug is a 17aa structured steroid , meaning it has been structured in a way which allows it to be orally bio-available, yet this has the negative effect of making Winstrol potentially harmful to the liver. It is therefore paramount the duration of a Winstrol cycle is limited, the dose of the drug is not excessive, the user does not stack it with other hepatotoxic compounds, does not drink alcohol whilst on cycle, and does not use Winstrol if they have an underlying medical condition which effects the livers health. There are supplements available which also help protect the liver (Milk Thistle, Liv-52 etc), and these would be advisable during any Winstrol cycle .
As a C17-aa anabolic steroid, Winstrol is hepatotoxic and will present stress to the liver. A common misconception many make is assuming only the oral version of this steroid is hepatotoxic. Winstrol can be found as an oral tablet or as an injectable solution but both forms are C17-aa and both stressful to the liver. In fact, injectable Winstrol is one of the only C17-aa injectable steroids. Many also inaccurately assume this is one of the most hepatotoxic anabolic steroids on the market; again this is false. Stanozolol will carry a greater hepatotoxicity than steroids like Anavar (Oxandrolone) but on a per milligram basis less hepatotoxic than steroids like Dianabol (Methandrostenolone).
Side effects that are a little more exclusive to Winstrol Depot have much to do with the uncomfortable and highly irritating injections (resulting almost exclusively from the suspension format). It is not uncommon to have very sore injection sites in the hours and days following administration, and to have a significant loss of range of motion of that muscle due to the pain. Often times, bodybuilders will even have to shift and schedule workouts around their Winstrol Depot injections, as the muscles injected might be too sore and tender to train soon afterwards. Winstrol itself carries with it comes significant side effects as well, most particularly the significant negative impacts on cholesterol levels in the body. Winstrol is notorious for reducing HDL (good cholesterol) levels and increasing LDL (bad cholesterol) levels in the body, which can contribute to increased risk for cardiovascular disease if left negatively altered for extended periods of time. Proper supplementation with cardiovascular supportive nutrients and compounds are highly advised. Being that Winstrol Depot is also C17AA modified, it does exhibit potential liver toxicity, although less so than its oral counterpart. Regardless, it is highly advised to include proven effective liver support compounds (such as TUDCA and/or NAC) during a cycle of Winstrol Depot.