Certain drugs such as troleandomycin (TAO), erythromycin ( Ery-Tab , EryPed 200), and clarithromycin ( Biaxin ) and ketoconazole ( Nizoral ) can reduce the ability of the liver to metabolize (breakdown) corticosteroids and this may lead to an increase in the levels and side effects of corticosteroids in the body. On the other hand, phenobarbital, ephedrine , phenytoin ( Dilantin ), and rifampin ( Rifadin , Rimactane ) may reduce the blood levels of corticosteroids by increasing the breakdown of corticosteroids by the liver. This may necessitate an increase of corticosteroid dose when they are used in combination with these drugs.
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With the increasing prevalence of allergic conditions, many studies have examined risk factors for allergies and how to modify these to potentially prevent allergies. The development of allergies results from a complex interplay between a person’s genetic make-up (genotype) and its interaction with the environment (phenotype). Having family members with allergic conditions increases the risk of allergy. Numerous environmental influences may also affect the development of allergy, such as breastfeeding, cesarean sections, diet during pregnancy, vitamin D levels, use of antibiotics, use of probiotics, animal exposures, pollutant exposure, and diet during infancy. Of all the factors studied to date, it appears that introducing highly allergic foods into the child’s diet before one year of age may decrease the risk of food allergy, particularly peanut allergy. Allergen immunotherapy (allergy shots) have also been shown to decrease the risk of developing future environmental allergies and asthma. Finding additional ways to prevent allergic conditions remains an active area of research.