Define anabolic window

A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.

Vitalstrength Protein Blend (94%) (Instantised Whey Protein Concentrate, Instantised Cross Flow Microfiltered (MF) and Ultrafiltered (UF) Whey Protein Isolate, Calcium Caseinate (contains concentrations of beta lactoglobulin, glycomacropeptide, alpha lactalbumin, immunoglobulin, bovine serum albumin)), Fructose, T4 Thermophase (African Mango Extract, L-Carnitine, Chromium Picolinate, Choline, Colour (120)), Flavours, Guar Gum, Sweetener (Sucralose). [Cocoa in Chocolate Blast flavour only. Colour (124) in Wild Strawberry flavour only]. Made in Australia from local and imported ingredients.

Dr Gougeon, also points out that Diabetes may need to ensure they keep this protein load in a meal to an optimal level not to induce this insulin spike “because in older adults it is an adequate protein or leucine content of a meal that regulates the mTOR signalling pathway of muscle protein synthesis and not insulin and energy as in children and young adults. This indicates that to optimize skeletal muscle protein synthesis, particularly in older persons with type 2 diabetes predisposed to sarcopenia, sufficient protein (w30 g) should be provided at every meal , including breakfast.”

Define anabolic window

define anabolic window

Media: