Potency of steroid drugs

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"Axis Recovery"

  • Slow reduction in dose over extended period of time
  • change dose rate every 3-4 weeks, change to EOD for first reduction
  • No ACTH (maintains negative feedback on hypothalamus)
  • Remember extra pred. for "stress"
  • Daily replacement therapy
    • Prednisone or prednisolone preferred
    • 1 mg/kg of hydrocortisone activity each day (dog)
    • - mg/kg prednisone, prednisolone "normal" secretion rate not known for other species
  • "Stressful" Situations
    • additional prednisone or prednisolone
Anti-inflammatory and Anti-immunologic Therapy Steroids are potent drugs for interrupting events triggered at the cell membrane (prostaglandins, phospholipase, etc.), and cell mediated immunity (antigen recognition, cell migration, etc.)

Occlusive Dressing Technique

Occlusive dressings may be used for the management of psoriasis or other recalcitrant rub a small amount of cream into the lesion until it disappears. Reapply the preparation leaving a thin coating on the lesion, cover with pliable nonporous film, and seal the edges. If needed, additional moisture may be provided by covering the lesion with a dampened clean cotton cloth before the nonporous film is applied or by briefly wetting the affected area with water immediately prior to applying the medication. The frequency of changing dressings is best determined on an individual basis. It may be convenient to apply Triamcinolone acetonide cream under an occlusive dressing in the evening and to remove the dressing in the morning (., 12-hour occlusion). When utilizing the12-hour occlusion regimen, additional cream should be applied, without occlusion, during the day. Reapplication is essential at each dressing change. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.

Potency of steroid drugs

potency of steroid drugs


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