Oxycodone is an alternative for patients with morphine intolerance or allergy. However, it may have a higher risk of abuse and should be used with caution in patients with higher risk scores. Long-acting oxycodone is not recommended for patients with chronic pain because it is not truly long-acting, is expensive, and has a high street value. Transdermal fentanyl may be a better alternative, although it is expensive and can produce tolerance relatively quickly. Fentanyl is lipophilic, and absorption is affected in patients with little subcutaneous fat and in those prone to edema at application sites.