Brian Griffin (voiced by Seth MacFarlane) is the family's anthropomorphic talking white Labrador Retriever and the best friend of both Peter and Stewie. He and Stewie are often at the center of the show's most critically acclaimed episodes, most notably the " Road to... " episodes, where he and Stewie go on road-trips together. Brian is portrayed as an intellectual—a Brown University attendee—who often serves as the family's voice of reason, pointing out how ridiculous Peter's ideas are. He is not-so-secretly in love with Lois and is an unsuccessful, unemployed writer.
Seth MacFarlane has gathered a diverse cast of Hollywood actors to voice the Griffin family and their neighbors. In addition to providing multiple voices himself, MacFarlane recruited veteran actors Seth Green, Mila Kunis, Patrick Warburton and Adam West to contribute to the cast. The show uses a wide variety of techniques to keep the viewer entertained. MacFarlane frequently employs original songs in the show in addition to the comic flashbacks and unusual situations. These methods have been widely praised by critics for the show remaining fresh and unpredictable. The end result is a show which finds humor in television, pop culture and every day life.
Stewie has twice had a relationship with another young toddler/beauty queen named Olivia . He also became sexually aroused while watching the female cheerleaders undress. Stewie also came close to having sex with Connie DiMico in " McStroke ". In Stewie Griffin: The Untold Story , his older self had sex with a girl named Fran for 8 seconds - then cried for 40 minutes. Stewie also became furious when he discovered that his future self was a virgin. At first sight, Stewie was also instantly attracted to Jillian. He is also easily annoyed by Jasper , Brian's gay cousin. Stewie falls in love with his babysitter in " 8 Simple Rules for Buying My Teenage Daughter ". In " Breaking Out is Hard to Do " he complains that there was not a single female baby in Asiantown . Also, in "Ocean's Three and a Half", Stewie falls madly in love with Susie Swanson , the Swanson's new baby, and tries to impress her with a song but by the time the episode was over he had lost interest in her only to fall in love with Bryan Adams.